Tag: iit mandi

  • IIT Mandi researchers identify key risk factors for cardiovascular diseases in adults

    IIT Mandi researchers identify key risk factors for cardiovascular diseases in adults



    Shimla: Indian Institute of Technology (IIT) Mandi researchers have conducted a study to identify the most significant risk factors for cardiovascular diseases (CVDs) among adults aged 45 and above in India. The study found that environmental exposure is a significant risk factor for the occurrence and progression of CVDs in older adults in India.
    A majority of the population of India resides in rural areas and uses unclean fuels for cooking and other purposes, exposing them to harmful smoke emitted from burning them. Second-hand smoke exposure, commonly referred to as passive smoking, is believed to have similar cardiovascular effects and risks comparable to active smoking.
    CVDs are a leading cause of mortality worldwide, claiming the lives of around 17.9 million people annually. The researchers analysed data from more than 59000 individuals aged 45 and above in both rural and urban India and arrived at the predominant risk factors of the disease.
    The details of the research have been published in the journal, Current Problems in Cardiology (Elsevier) – Impact Factor: 16.464, in a paper co-authored by Ramna Thakur Associate Professor, School of Humanities and Social Sciences, IIT Mandi and her research scholars Gayathri and Sujata.
    Explaining the basis of the research, Ramna Thakur, said that there are several traditional risk factors for CVDs, including high systolic blood pressure, low HDL cholesterol, obesity, unhealthy food, poor nutritional status, age, family history, physical inactivity, smoking, and alcohol consumption. Additionally, exposure to air pollutants is another significant risk factor.
    “We aimed to cluster these risk factors into different groups and identify the exclusive individual effect of each group on CVDs prevalence among adults aged 45 and above in India,” she said.
    The study also identified behavioural risk factors such as physical inactivity leading to CVDs. The study showed that the effect of physiological factors, which include diabetes, high cholesterol, depression, and being overweight or obese, is particularly serious. The sedentary lifestyle of people, the adoption of fast-food culture, and urbanization are some of the reasons for the prevalence of these physiological factors.
    To reduce indoor air pollution and safeguard public health, the study recommends promoting the use of cleaner technology such as liquified petroleum gas, solar, electricity, and biogas. Engaging in light to moderate physical activity in middle or older age has a considerable positive impact on the reduction of the risk of cardiovascular disease and overall mortality. Risk awareness programmes associated with alcohol and tobacco use could also be an effective method to curb their use and reduce the probability of getting diagnosed with CVDs.



  • IIT Mandi Scientist Creates math Models to Find out How Non-Invasive Brain Stimulation Affects us

    IIT Mandi Scientist Creates math Models to Find out How Non-Invasive Brain Stimulation Affects us

    Acollaborative research team comprising scientists from IIT Mandi and National Brain Research Centre, India and University at Buffalo, USA, performed mathematical simulation studies on non-invasive brain stimulation techniques.

    The results of the team’s recent work in the area have been published as an abstract in the journal, Brain Stimulation. The abstract has been co-authored by Dr Shubhajit Roy Chowdhury from IIT Mandi, Dr Yashika Arora from National Brain Research Centre, India, and Dr Anirban Dutta of the University at Buffalo.

    What is non-invasive brain stimulation?

    Transcranial electrical stimulation (tES) is a non-invasive brain stimulation technique that passes an electrical current through sections of the brain to study or alter brain function.

    This is not a new concept, and dates back even before the discovery of electricity. In the first century AD, the Roman physician Scribonius Largus applied the black torpedo, an electric shock producing fish, to the head of the emperor to alleviate his headache.

    Soon after the discovery of electricity in the 18th century, portable electrostimulation devices were designed to treat various neurological syndromes including headaches.

    In modern-day tES, multiple electrodes are applied to the scalp of the patient, and current is passed between the electrodes through the soft tissue and skull. Part of the current penetrates into the brain and affects the nerves, resulting in altered activity. Beyond being explored as a curative, tES is considered useful to map the functions of the brain, i.e., to understand the relationship between the brain part and behaviours/actions.

    Brain simulation is the concept of creating a functioning computer model of a brain or part of a brain.

    Why is it important to study the effects of non-invasive brain stimulation?

    Given the important nature of the brain, the use of electricity on it can be dangerous if outcomes are not known.

    The response of various blood vessels in the cranium and various neurological pathways to tES must be clearly understood to get the maximum benefit of the procedure, with minimum damage.

    The multi-institutional research team has developed a mathematical model to understand the physiological effects of non-invasive brain stimulation.

    How does this IIT Mandi research help in understanding the effects of tES?

    Highlighting his research, Dr. Shubhajit Roy Chowdhury, Associate Professor, School of Computing & Electrical Engineering, IIT Mandi, said, “We simulated a physiologically detailed mathematical model of the neurovascular unit (NVU) with four compartments: synaptic space, astrocyte space, perivascular space, and arteriole smooth muscle cell space, called NeuroVascular Units or NVU.”

    The mathematical model involved the application of perturbations of varying frequencies (0.1 Hz to 10 Hz) to simulate the electrical field, to the four nested NVU compartmental pathways and analysed the changes in blood vessel diameter in response to the frequencies.

    Three types of non-invasive brain stimulation transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS) and transcranial oscillatory current stimulation (tOCS) were modelled to investigate their physiological effects.

    The initial tES effects on the blood vessels were also found to occur via the perivascular space – a fluid-filled space surrounding the blood vessels in the brain.

    How can this research help in the medical field?

    “Our study can help brain- and neuro-specialists plan patient-specific restorative neurorehabilitation activities for stroke, post-traumatic brain injury, mild cognitive impairment, dementia, and other neuropsychiatric disorders,” said the lead researcher.

    Such a mathematical model based quantitative analysis would help in individualized therapeutic protocols for neuropsychiatric disorders.

    The team has planned experimental studies that involve blocking various pathways to validate their modelling results.

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